مقاله انگلیسی ایمنی مکمل های غذایی با آرجنین در افراد بالغ

13 شهریور 1397 | 14:59

مقاله انگلیسی ایمنی مکمل های غذایی با آرجنین در افراد بالغ
عنوان فارسی مقاله: ایمنی مکمل های غذایی با آرجنین در افراد بالغ
عنوان انگلیسی مقاله: Safety of dietary supplementation with arginine in adult humans
مجله/کنفرانس: Amino Acids
رشته های تحصیلی مرتبط: پزشکی
گرایش های تحصیلی مرتبط: متخصص تغذیه
کلمات کلیدی انگلیسی: Arginine; Health; Nutrition; Obesity; Safety; Supplementation
نوع نگارش مقاله: Original Article
نمایه: scopus - master journals - JCR - medline
DOI: doi.org/10.1007/s00726-018-2594-7
ناشر: Springer
نوع ارائه مقاله: ژورنالی
نوع مقاله: ISI
مقاله بیس: ✔️
سال انتشار مقاله: 2018
ایمپکت فاکتور(IF): 2.906(2017)
شاخص H_index: 98
SJR: 1.135
شناسه ISSN: 0939-4451
فرمت مقاله انگلیسی: PDF
تعداد صفحات مقاله انگلیسی: 15
کد محصول: EN53
فهرست انگلیسی مطالب
Abstract

Introduction

Study subjects and methods
-Human subjects
-Oral administration of Arg
-Laboratory analyses
-Statistical analysis

Results
-Physical characteristics of study subjects
-Food intake of study subjects
-Concentrations of hormones, protein and electrolytes, and enzymatic activities of transaminases in serum
-Concentrations of urea, ammonia, creatinine, and amino acids in serum
-Concentrations of glucose and lipids in serum
-Urine volume and urinary excretion of metabolites

Discussion

References
نمونه متن انگلیسی
Abstract

Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m2. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.
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